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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN12 All Species: 12.73
Human Site: S596 Identified Species: 28
UniProt: Q05209 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05209 NP_001124480.1 780 88120 S596 P L F R T P L S F T N P L H S
Chimpanzee Pan troglodytes XP_519168 792 88529 S608 P L F R T P L S F T N P L H S
Rhesus Macaque Macaca mulatta XP_001082837 733 82786 N554 I P D L S E G N S S D I H C Q
Dog Lupus familis XP_540396 757 85032 S573 P L F R A P L S F T N P L H S
Cat Felis silvestris
Mouse Mus musculus P35831 775 86973 S596 P L L K A P L S F T N P L H S
Rat Rattus norvegicus NP_476456 766 85965 A587 N S S P L P R A P L S F T N P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507461 747 83881 P567 S T P P P R A P L C F T N P L
Chicken Gallus gallus XP_415970 1211 131521 C1017 V S L R A P L C F T N P L H S
Frog Xenopus laevis NP_001084841 660 74123 N481 S V V G L P S N I C T D C T S
Zebra Danio Brachydanio rerio NP_956963 570 64484 L391 T Y H P K P L L S D P E P S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 L647 K V K D T T E L P S S K N F R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 91.4 88 N.A. 82.8 83.5 N.A. 74.6 48.3 58.2 46.7 N.A. N.A. N.A. N.A. 28.9
Protein Similarity: 100 95.4 92.3 91 N.A. 88.3 88.8 N.A. 81.1 53.5 66.9 57.4 N.A. N.A. N.A. N.A. 44
P-Site Identity: 100 100 0 93.3 N.A. 80 6.6 N.A. 0 66.6 13.3 13.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 26.6 93.3 N.A. 86.6 26.6 N.A. 0 66.6 26.6 13.3 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 28 0 10 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 19 0 0 10 10 0 % C
% Asp: 0 0 10 10 0 0 0 0 0 10 10 10 0 0 10 % D
% Glu: 0 0 0 0 0 10 10 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 28 0 0 0 0 0 46 0 10 10 0 10 0 % F
% Gly: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 10 46 0 % H
% Ile: 10 0 0 0 0 0 0 0 10 0 0 10 0 0 0 % I
% Lys: 10 0 10 10 10 0 0 0 0 0 0 10 0 0 0 % K
% Leu: 0 37 19 10 19 0 55 19 10 10 0 0 46 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 0 19 0 0 46 0 19 10 0 % N
% Pro: 37 10 10 28 10 73 0 10 19 0 10 46 10 10 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Q
% Arg: 0 0 0 37 0 10 10 0 0 0 0 0 0 0 10 % R
% Ser: 19 19 10 0 10 0 10 37 19 19 19 0 0 10 55 % S
% Thr: 10 10 0 0 28 10 0 0 0 46 10 10 10 10 0 % T
% Val: 10 19 10 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _